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Grand Rounds 06/25/14 @ BID-Needham - George Stojan, MD  

Atherosclerosis in Systemic Lupus
Last Updated: Aug 12, 2014 URL: http://bidmc.libguides.com/Stojan Print Guide RSS Updates
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Speaker: Date: Topic

George Stojan, MD

June 25, 2014

Atherosclerosis in Systemic Lupus

      

    Responsibility for Content

    The WebEx video, PowerPoint presentation, take-away points and article links were sent by the Medical Library and the CME Committee.

    Diane E. Young, Information Specialist

    dyoung3@bidmc.harvard.edu

     

        

      To Obtain Other Articles Cited

      If you wish to obtain any other articles cited in the presentation, please contact Diane Young.

          

        Take-Away Points of the Presentation

        —  Accelerated atherosclerosis and its long term sequelae are the major causes of late mortality in SLE.

        —  Treatment strategies include an aggressive approach in therapy of traditional cardiovascular risk factors with targets equivalent to the ones used for established CVD.

        —  Smoking inhibits the effect of the antimalarials and should be immediately addressed.

        —  In the absence of contraindications, hydroxychloroquine should be used in EVERY patient.

        —  Despite the negative results of the LAPS trial, statins remain the mainstay of treatment of hyperlipidemia, while fish oil and niacin use are discouraged.

        —  ACE inhibitors should be used as first line agents for treatment of hypertension to a goal of less than 120mmHg systolic.

        —  Aspirin should be used in any patient with SLE who has a history of CVD, positive antiphospholipid antibodies or lupus anticoagulant, history of hypertension, diabetes mellitus, hypercholesterolemia and a history of smoking.

        —  Despite the lack of conclusive benefit, the treatment of vitamin D deficiency and hyperhomocysteinemia is encouraged.

         

            
           

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