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Grand Rounds 10/08/14 @ BID-Needham: Dr. Vasileios C. Kyttaris  

New Treatments for Rheumatic Diseases
Last Updated: Aug 30, 2016 URL: http://bidmc.libguides.com/Kyttaris Print Guide RSS Updates
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Speaker: Date: Topic

Vasileios C. Kyttaris, MD

Oct. 8, 2014

New Treatments for Rheumatic Diseases

      

    Responsibility for Content

    The WebEx video, PowerPoint presentation, take-away points, and article links were sent by the Medical Library and the CME Committee.

    Diane E. Young, Information Specialist

    dyoung3@bidmc.harvard.edu

     

        

      Take-Away Points of the Presentation

      1. Most rheumatoid arthritis patients are now on methotrexate.

      2. Standard treatment for RA is to start methotrexate immediately, and if there is no response after 6 months, to try the TNF-a inhibitors.

      3. Patients treated with TNF-α inhibitors are at higher risk for infections with reactivation of tuberculosis being a major concern. It is unclear whether these agents increase the risk of malignancies.  Lipids are a concern with tocilizumab, not TNF-α inhibitors.

      4. Newer drugs include tocilizumab, tofacitinib, ustekinumab, and apremilast.

       

      5. Belimumab is the first drug in the past 50 years to be approved for SLE.

      6. We presently do not have any biomarkers to predict therapeutic response.

      7. Cost is a huge concern with the newer drugs.

          

        Links to Abstracts of Articles Cited (contact Diane Young for full-text articles at dyoung3@bidmc.harvard.edu)

         

        PDF of the PowerPoint Presentation

        WebEx Video of the Presentation

         

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