Speaker: Date: Topic
James V. Hennessey, MD
Dec 4, 2013
L-Thyroxine Therapy: Reducing Variability of Outcomes and Getting It Right
Responsibility for Content
The powerpoint presentation, take-away points and article links were sent by the Medical Library and the CME Committee.
Diane E. Young, Information Specialist
Take-Away Points of the Presentation
1. L-thyroxine therapy is frequently associated with abnormal thyroid function test results.
2. Patient, pharmacist and physician factors play a significant role in explaining the variability of results.
3. A systematic approach to analyzing patient factors should result in improved outcomes.
Links to Articles Cited in the Presentation
- Bach-Huynh TG et al: Timing of levothyroxine administration affects serum thyrotropin concentration.
- Blakesley V et al: Are bioequivalence studies of levothyroxine sodium formulations in euthyroid volu
- Diez JJ: Hypothyroidism in patients older than 55 years: an analysis of the etiology and assessment
- Flynn RW et al: Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular di
- Garber JR et al: Clinical practice guidelines for hypothyroidism in adults: cosponsored by the Ameri
- Hennessey JV et al: Adverse event reporting in patients treated with levothyroxine: results of the p
- Kang GY et al: Thyroxine and triiodothyronine content in commercially available thyroid health suppl
- Lee JK et al: Effect of a pharmacy care program on medication adherence and persistence, blood press
- Lips DJ et al: Diagnosis and treatment of levothyroxine pseudomalabsorption. Neth J Med 2004;62(4):1
- Okosieme OE et al: Adequacy of thyroid hormone replacement in a general population. QJM 2011;104(5):
- Silva Perez CL et al: Serum thyrotropin levels following levothyroxine administration at breakfast.
- Somwaru LL et al: High frequency of and factors associated with thyroid hormone over-replacement and
- Stelfox HT et al: An evaluation of the adequacy of outpatient monitoring of thyroid replacement ther